SENCA: A Multilayered Codon Model to Study the Origins and Dynamics of Codon Usage
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چکیده
منابع مشابه
SENCA: A Multilayered Codon Model to Study the Origins and Dynamics of Codon Usage
Gene sequences are the target of evolution operating at different levels, including the nucleotide, codon, and amino acid levels. Disentangling the impact of those different levels on gene sequences requires developing a probabilistic model with three layers. Here we present SENCA (site evolution of nucleotides, codons, and amino acids), a codon substitution model that separately describes 1) n...
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Most genomes are heterogeneous in codon usage, so a codon usage study should start by defining the codon usage that is typical to the genome. Although this is commonly taken to be the genomewide average, we propose that the mode-the codon usage that matches the most genes-provides a more useful approximation of the typical codon usage of a genome. We provide a method for estimating the modal co...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2016
ISSN: 1759-6653
DOI: 10.1093/gbe/evw165